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Scientists have reprogrammed mouse cells into pluripotent stem cells using a gene from choanoflagellates, single-celled organisms related to animals. This breakthrough demonstrates that key genes driving stem cell formation existed in unicellular ancestors nearly a billion years ago.
The resulting stem cells were used to create a chimeric mouse, showcasing how ancient genetic tools can integrate with modern mammalian biology. This discovery redefines the evolutionary origins of stem cells and may inform regenerative medicine advancements.
Key Facts:
- A choanoflagellate gene replaced mouse Sox2 to reprogram cells into stem cells.
- The reprogrammed stem cells contributed to a chimeric mouse’s development.
- The findings suggest stem cell-related genes predate multicellular organisms.
